Prof. Dr. Tanja Vogel
Prof. Dr. Tanja VogelInstitute of Anatomy and Cell Biology Tel.: +49-761-203 5086 |
Curriculum vitae |
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1. General Information | |
Name | Vogel, Tanja, Prof. Dr. |
Position | Professor (W3) |
2. Scientific education | |
10/1988-01/1994 |
Study of Biochemistry, University of Hannover |
3. Scientific Education and Appointments | |
07/1994-11/1997 | PhD in human genetics, Instiute for Human Genetics, Hannover Medical School |
2010 | Habilitation in Anatomy, Universitäty Medicine Göttingen, Department of Neuroanatomy |
4. Professional Career | |
10/1997-01/2000 | Postdoctoral fellow,MRC Human Genetics Unit, Edinburgh, UK |
02/2000-07/2005 | Postdoctoral fellow, MPI for Biophysical Chemistry, Göttingen |
08/2005-03/2011 | Group leader, Department of Neuroanatomy, Centre of Anatomy, University Medicine Göttingen |
04/2011-01/2016 | Associate Professor (W2), Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg |
04/2014-10/2016 | Managing Director of the Institute for Anatomy and Cell Biology, University of Freiburg |
01/2016-present | Professor (W3), Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg |
5. Other Qualifications | |
1994-1997 | Doctoral fellowship from the DFG Graduate School “Molecular Pathophysiology of Cell Growth” |
1998-2000 | Travelling Research Fellowship of the Wellcome Trust, UK |
2000-2001 | Postdoctoral fellowship of the Max-Planck-Society |
2011 | Award for the best Habilitation of the University Medicine Göttingen |
Publications
Original paper |
Schäffner I, Wittmann MT, Vogel T, Lie DC. Differential vulnerability of adult neurogenic niches to dosage of the Neurodevelopmental-disorder linked gene Foxg1. Mol. Psychiachtry. (2022). |
Treppner M, Salas-Bastos A, Hess M, Lenz S, Vogel T, Binder H.Synthetic single cell RNA sequencing data from small pilot studies using deep generative models. Sci Rep. 11(1):9403-11. (2021). |
Ferrari F, Arrigoni L, Franz H, Izzo A, Butenko L, Trompouki E, Vogel T, Manke T. DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility. Nat Commun 11, 5200 (2020). |
Gray de Cristoforis A, Ferrari F, Clotman F, Vogel T. Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. Mol Brain. 2020;13(1):85. Published 2020 May 29. |
Franz H, Villarreal A, Heidrich S, Videm P, Kilpert F, Mestres I, Calegari F, Backofen R, Manke T, Vogel T (2019) DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex. Nucleic Acids Res 47(1):168-183 |
Bovio PP, Franz H, Heidrich S, Rauleac T, Kilpert F, Manke T, Vogel T (2019) Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo. Mol Neuro (56): 4273-4287 https://doi.org/10.1007/s12035-018-1377-1 |
Weise SC, Arumugam G, Villarreal A, Videm P, Heidrich S, Nebel N, Dumit VI, Sananbenesi F, Reimann V, Craske M, Schilling O, Hess W, Fischer A, Backofen R, Vogel T (2018) FOXG1 regulates PRKAR2B transcriptionally and posttranscriptionally via miR200 in the adult hippocampus. Mol Neuro(56):5188-5201 https://doi.org/10.1007/s12035-018-1444-7 |
Weise SC, Villarreal A, Heidrich S, Dehghanian F, Schachtrup C, Nestel S, Schwarz J, Thedieck K, Vogel T (2018) TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal Forebrain. Front Cell Neurosci,12. http://doi.org/10.3389/fncel.2018.00448 |
Hoffmann N, Weise SC, Marinaro F, Vogel T and De Pietri Tonelli D (2018) DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex. Front. Neurosci. 12:281. |
Bovio P, Roidl D, Heidrich S, Vogel T, Franz H (2018) Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark. J Vis Exp Jan 26;(131). https://doi.org/10.3791/56631 |
Grassi D, Franz H, Vezzali R, Bovio P, Heidrich S, Dehghanian F, Lagunas N, Belzung C, Krieglstein K, Vogel T (2017) Neuronal Activity, TGFβ-Signaling and Unpredictable Chronic Stress Modulate Transcription of Gadd45 Family Members and DNA Methylation in the Hippocampus. Cereb Cortex:1–16. https://doi.org/10.1093/cercor/bhx095 |
Ehrmann I, Gazzara MR, Pagliarini V, Dalgliesh C, Chadegani MK, Xu Y, Cesari E, Danilenko M, Maclennan M, Lowdon K, Vogel T, Keskivali-Bond P, Wells S, Cater H, Fort P, Koref MS, Middei S, Sette C, Clowry GJ, Barash Y, Cunningham M, Elliott DJ (2016) A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior. Cell Rep 17(12):3269-3280. https://doi.org/10.1016/j.celrep.2016.12.002 |
Seehusen FA, Kiel K, Jottini S, Wohlsein P, Habierski A, Seibel K, Vogel T, Urlaub H, Kollmar M, Baumgärtner W, Teichmann U (2016) Axonopathy in the Central Nervous System Is the Hallmark of Mice with a Novel Intragenic Null Mutation of Dystonin. Genetics. 204(1): 191-203. |
Vezzali R, Weise SC, Hellbach N, Machado V, Heidrich S, Vogel T (2016) The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Oncotarget, 7(25): 37436-37455. |
Roidl D, Hellbach N, Bovio P, Villarreal A, Heidrich S, Nestel S, Grüning B, Bönisch U, Vogel T (2016) DOT1L activity promotes proliferation and protects cortical neural stem cells from activation of ATF4-DDIT3-mediated ER stress in vitro. Stem Cells 34(1): 233-45. |
Kosinsky RL, Wegwitz F, Hellbach N, Dobbelstein M, Mansouri A, Vogel T, Begus-Nahrmann Y, Johnsen SA (2015) Usp22 deficiency impairs intestinal epithelial lineage specification in vivo. Oncotarget 6(35):37906-18. |
Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T (2014) Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet 23(23):6177-90. https://doi.org/10.1093/hmg/ddu338 |
Wahane SD, Hellbach N, Prentzell MT, Weise SC, Vezzali R, Kreutz C, Timmer J, Krieglstein K, Thedieck K, Vogel T (2014) PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2. J Neurochem.130(2): 255-67. |
Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, Snaidero N, Vogel T, Shchebet TA, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beissbarth T, Johnsen SA (2012) The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells. Molecular Cell 46(5): 705–713. |
Büttner N, Johnsen SA, Kügler S, Vogel T (2010) Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.Proc Natl Acad Sci U S A 107(15): 7042-7. |
Overview articles |
Akol I., Gather F., Vogel T. Paving Therapeutic Avenues for FOXG1 Syndrome: Untangling Genotypes and Phenotypes from a Molecular Perspective. Int J Mol Sci 23: 954. 2022. https://doi.org/10.3390/ijms23020954 |
Villarreal A., Vogel T. Different flavors of astrocytes: Revising the origins of astrocyte diversity and epigenetic signatures to understand heterogeneity after injury. Int J Mol Sci, 22:6867. 2022. https://doi.org/10.3390/ijms22136867 |
Hou PS, hAilín DÓ, Vogel T, Hanashima C. Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders. Front Cell Neurosci. 2020;14:35. Published 2020 Feb 25. https://dx.doi.org/10.3389/fncel.2020.00035 |
Vogel T, Lassmann S (2014) Epigenetics: development, dynamics and disease. Cell Tissue Res. 356:451-455. https://doi.org/10.1007/s00441-014-1916-7 |
Backofen R, Vogel T (2014) Biological and bioinformatical approaches to study crosstalk of long-non-coding RNAs and chromatin-modifying proteins. Cell Tissue Res. 356:507-526. https://doi.org/10.1007/s00441-014-1885-x |
Roidl D, Hacker C (2014) Histone methylation during neural development. Cell Tissue Res. 356:539-552. https://doi.org/10.1007/s00441-014-1842-8 |
Vogel T, Schmidtke J (1998) Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein". Cytogenet Cell Genet 80: 209-213. https://doi.org/10.1159/000014982 |
Book chapter |
Insulin/IGF-Signalling in Embryonic and Adult Neural Proliferation and Differentiation in the Mammalian Central Nervous System |
Scientific publications in Medline
Research Database University Freiburg