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Prof. Dr. Klaus Unsicker

Prof. Dr. Klaus Unsicker

Institute of Anatomy & Cell Biology
University of Freiburg
Albertstr. 17
D-79104 Freiburg

Tel.: +49-761-203 5193
Fax: +49-761-203 5091



Curriculum vitae

since 2009 Guest Professor, Department of Molecular Embryology, Medical Faculty, University of Freiburg, Germany
2006 Visiting Professor, Institute of Biotechnology, University of Helsinki, Finland
2000 - 2004 Founding Member and Director, Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, Germany
1992 - 2009 Full Professor, Anatomy & Cell Biology, Director Neuroanatomy, University of Heidelberg, Germany
1989 - 1990 Visiting Professor, Cold Spring Harbor Laboratories, NIH / NCI Laboratory for Chemoprevention (M. Sporn), Bethesda, Maryland, USA
1983 - 1984 Visiting Professor, Department of Biology (S. Varon), University of California at San Diego, USA
1978 - 1992 Full Professor, Anatomy & Cell Biology, Director Neuroanatomy, University of Marburg, Germany
1976 - 1977 Associate Professor, Anatomy, University of Kiel, Germany
1970 - 1975 Postdoctoral Fellow
1973 Habilitation / Docent, Anatomy, University of Kiel, Germany
1968 M.D., Anatomy, University of Kiel, Germany
1961 – 1968 Medical School, Universities of Bonn, Munich, Kiel, Germany

Project coordination, Membership in collaborative research projects (Selection)

2009 - 2012 Member DFG Collaborative Research Grant (SFB) 592 “Signaling mechanisms in embryogenesis and organogenesis”
2004 - 2009 Vice Speaker SFB / DFG Collaborative Research Grant (SFB) 636 „Learning and Memory“
2003 - 2009 Coordinator Partnership Hebrew University Jerusalem / University Heidelberg
2001 - 2007 Founding Member BIOQUANT Heidelberg, Germany
1999 - 2007 Speaker SFB / DFG Collaborative Research Grant (SFB) 488 „Molecular and Cellular Bases of Neural Development“
1998 - 2006 Speaker DFG Collaborative Research Group “Central Aminergic Systems”
1994 - 1999

Member DFG Collaborative Research Grant (SFB) 317 “Molecular


Functions in Scientific Societies and Committees (Selection)

2010 - 2014 Member Scientific Advisory Board, Neuroscience Center, University of Helsinki, Finland
2009 - 2010 President Evaluation Committee for Biology, ETH Zurich, Switzerland
2005 - 2006 Rapporteur, Neuroscience Institutes Seewiesen/Andechs, Martinsried, Göttingen, Germany
2004 - 2012 Speaker Neuroscience Panel, German Research Foundation (DFG)
1998 - 2000 President International Society for Developmental Neuroscience
1995 - 1999 Member Committees for Collaborative Research Grants, German Research Foundation (DFG)
1994 - 1995 President Anatomical Society (Anatomische Gesellschaft)
1992 - 1996 Scientific Advisory Board, Society of German Natural Scientists and Physicians (Gesellschaft deutscher Naturforscher und Ärzte, GdNÄ)
1990 Ad hoc Member National Institutes of Health USA, Neuroscience Panel B

Honours and Awarded Memberships (Selection)

2007 Honorary Membership Romanian Society for Cell Biology
2003 Honorary doctorate, University of Marburg, Germany
2001 Aschoff Medal, Medical Society and Faculty, University of Freiburg, Germany
1997 Max-Planck Research Award for International Cooperation
1997 Jan Swammerdam Lecture Amsterdam, the Netherlands
1992 Member of the German Academy of Sciences Leopoldina
1981 Research Medal University of Helsinki, Finland


  Casanovas G, Vujić Spasic M, Casu C, Rivella S, Strelau J, Unsicker K, Muckenthaler MU.
The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice. Haematologica. 2013 Mar;98(3):444-7.
  Schober A, Parlato R, Huber K, Kinscherf R, Hartleben B, Huber TB, Schütz G, Unsicker K.
Cell loss and autophagy in the extra-adrenal chromaffin organ of Zuckerkandl are regulated by glucocorticoid signalling. J Neuroendocrinol. 2013 Jan;25(1):34-47.
  Unsicker K, Huber K, Schober A, Kalcheim C.
Resolved and open issues in chromaffin cell development. Mech Dev. 2013 Jun-Aug;130(6-8):324-9.
  Unsicker K.
Neurotrophic molecules in the treatment of neurodegenerative disease with focus on the retina: status and perspectives. Cell Tissue Res. 2013 Aug;353(2):205-18.
  Charalambous P, Wang X, Thanos S, Schober A, Unsicker K.
Regulation and effects of GDF-15 in the retina following optic nerve crush. Cell Tissue Res. 2013 Jul;353(1):1-8.
  Shtukmaster S, Schier MC, Huber K, Krispin S, Kalcheim C, Unsicker K.
Sympathetic neurons and chromaffin cells share a common progenitor in the neural crest in vivo. Neural Dev. 2013 Jun 18;8:12.
  Stubbusch J, Narasimhan P, Huber K, Unsicker K, Rohrer H, Ernsberger U.
Synaptic protein and pan-neuronal gene expression and their regulation by Dicer-dependent mechanisms differ between neurons and neuroendocrine cells. Neural Dev. 2013 Aug 20;8:16.
  Narayanan KL, Subramaniam S, Bengston CP, Irmady K, Unsicker K, von Bohlen und Halbach O.
Role of transient receptor potential channel 1 (TRPC1) in glutamate-induced cell death in the hippocampal cell line HT22. J Mol Neurosci. 2014 Mar;52(3):425-33.

Carrillo-García C, Prochnow S, Simeonova IK, Strelau J, Hölzl-Wenig G, Mandl C, Unsicker K, von Bohlen Und Halbach O, Ciccolini F.
Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice. Development. 2014 Feb;141(4):773-83.

  Irmady K, Jackman KA, Padow VA, Shahani N, Martin LA, Cerchietti L, Unsicker K, Iadecola C, Hempstead BL.
Mir-592 regulates the induction and cell death-promoting activity of p75NTR in neuronal ischemic injury. J Neurosci. 2014 Feb 26;34(9):3419-28.
  Dokter M, Busch R, Poser R, Vogt MA, von Bohlen Und Halbach V, Gass P, Unsicker K, von Bohlen Und Halbach O.
Implications of p75NTR for dentate gyrus morphology and hippocampus-related behavior revisited. Brain Struct Funct. 2015 May;220(3):1449-62.
  Stubbusch J, Narasimhan P, Hennchen M, Huber K, Unsicker K, Ernsberger U, Rohrer H.
Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23.
  Poser R, Dokter M, von Bohlen Und Halbach V, Berger SM, Busch R, Baldus M, Unsicker K, von Bohlen Und Halbach O.
Impact of a deletion of the full-length and short isoform of p75NTR on cholinergic innervation and the population of postmitotic doublecortin positive cells in the dentate gyrus. Front Neuroanat. 2015 May 27;9:63.
  Wang X, Krebbers J, Charalambous P, Machado V, Schober A, Bosse F, Müller HW, Unsicker K.
Growth/differentiation factor-15 and its role in peripheral nervous system lesion and regeneration. Cell Tissue Res. 2015 Nov;362(2):317-30. Jun 16. Erratum in: Cell Tissue Res. 2015 Oct;362(1):267.
Saunders NR, Dziegielewska KM, Unsicker K, Joakim Ek C.
Delayed astrocytic contact with cerebral blood vessels in FGF-2 deficient mice does not compromise permeability properties at the developing blood-brain barrier. Dev Neurobiol. 2016 Feb 5. doi: 10.1002/dneu.22383. [Epub ahead of print]
Machado V, Haas SJ, von Bohlen Und Halbach O, Wree A, Krieglstein K, Unsicker K, Spittau B.
Growth/differentiation factor-15 deficiency compromises dopaminergic neuron survival and microglial response in the 6-hydroxydopamine mouse model of Parkinson's disease.Neurobiol Dis. 2016 Apr;88:1-15. doi: 10.1016/j.nbd.2015.12.016. Epub 2015 Dec 28.


Current Research


Forschungsarbeiten in Medline

Research Database University of Freiburg