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Prof. Dr. Christian Schachtrup

Prof Dr. Christian Schachtrup

Institute of Anatomy and Cell Biology
Albert-Ludwigs University of Freiburg

D-79104 Freiburg im Breisgau

Tel.: +49 761 203 5101
Fax: +49 761 203 5091




Curriculum Vitae

  • 1994-1999 Biology Studies (Diploma Degree), University of Münster
  • 2000-2003 Dissertation in the lab of Prof. F. Spener, Institute of Biochemistry Münster
  • 2004 Visiting Scientist, Tohoku University, Sendai, Japan
  • 2005-2008 Postdoctoral Scientist, University of California, San Diego, USA
  • 2008-2010 Postdoctoral Scientist, Gladstone Institute of Neurological Disease, San Francisco, USA
  • 2010-2017 Group leader, Institute of Anatomy and Cell Biology, University of Freiburg
  • Since 2017 Heisenberg Professor (W3) of Anatomy focusing on experimental neuroregeneration, University of Freiburg

Scientific Focus

  • Coagulation cascade and fibrinolytic system in CNS disease
  • Molecular mechanisms of astrocyte activation and scar formation
  • Neural stem cells in neuronal regeneration

Selected publications

  • Bouderlique T, Peña-Pérez L, Kharazi S, Hils M, Li X, Krstic A, De Paepe A, Schachtrup C, Gustafsson C, Holmberg D, Schachtrup K, Månsson R The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification. Front Immunol. 2019 Mar 18;10:455. doi: 10.3389/fimmu.2019.00455. eCollection 2019.
  • Weise SC, Villarreal A, Heidrich S, Dehghanian F, Schachtrup C, Nestel S, Schwarz J, Thedieck K, Vogel T. TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal Forebrain. Front Cell Neurosci. 2018 Nov 28;12:448. doi: 10.3389/fncel.2018.00448. eCollection 2018.
  • Rauch KS, Hils M, Menner AJ, Sigvardsson M, Minguet S, Aichele P, Schachtrup C, Schachtrup K. Regulatory T cells characterized by low Id3 expression are highly suppressive and accumulate during chronic infection. Oncotarget. 2017, 27;8(61):102835-102851.
  • Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017, 96:1003-1012.
  • Rauch KS, Hils M, Lupar E, Minguet S, Sigvardsson M, Rottenberg ME, Izcue A, Schachtrup C, Schachtrup K. Id3 maintains Foxp3 expression in regulatory T cells by controlling a transcriptional network of E47, Spi-B and SOCS3. Cell Reports. 2016, 17:2827-2836.
  • Pfurr S, Chu Y-H, Bohrer C, Greulich F, Beattie R, , Mammadzada K, Hils M, Arnold SJ, Taylor V, Schachtrup K, Uhlenhaut HN, Schachtrup C. The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development. Development. 2017; 144:3917-3931.
  • Bohrer C, Pfurr S, Mammadzada K, Schildge S, Plappert L, Hils M, Pous L, Rauch K, Dumit V, Pfeifer D, Dengjel J, Kirsch M, Schachtrup K, Schachtrup C. The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes. EMBO J. 2015; 34:2804-19.
  • Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Perez A, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. Nuclear pore complex remodeling by the cleaved p75 neurotrophin receptor regulates TGF-beta signaling and astrocyte scar formation. Nat Neurosci. 2015; 18:1077-80.
  • Schachtrup C, Ryu JK, Helmrick M, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. Fibrinogen triggers astrocyte scar formation by promoting availability of active TGF-β after vascular damage. J Neurosci. 2010; 30:5843-5854.
  • Schachtrup C, Lu P, Jones LL, Lee JK, Lu J, Sachs BD, Zheng B, Akassoglou K. Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci USA. 2007; 104:11814-11819.

Research methods

  • STED microscopy
  • Animal models of CNS disorders