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Prof. Dr. Tanja Vogel


Prof. Dr. Tanja Vogel

Institute of Anatomy and Cell Biology
University of Freiburg
Albertstr. 17
D-79104 Freiburg

Tel.: +49-761-203 5086
Fax: +49-761-203 5091



Curriculum vitae

1. General Information  
Name Vogel, Tanja, Prof. Dr.
Position Professor (W3)
2. Scientific education  

Study of Biochemistry, University of Hannover

3. Scientific Education and Appointments
07/1994-11/1997 PhD in human genetics, Instiute for Human Genetics, Hannover Medical School
2010 Habilitation in Anatomy, Universitäty Medicine Göttingen, Department of Neuroanatomy
4. Professional Career  
10/1997-01/2000 Postdoctoral fellow,MRC Human Genetics Unit, Edinburgh, UK
02/2000-07/2005 Postdoctoral fellow, MPI for Biophysical Chemistry, Göttingen
08/2005-03/2011 Group leader, Department of Neuroanatomy, Centre of Anatomy, University Medicine Göttingen
04/2011-01/2016 Associate Professor (W2), Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg
04/2014-10/2016 Managing Director of the Institute for Anatomy and Cell Biology, University of Freiburg
01/2016-present Professor (W3), Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg
5. Other Qualifications  
1994-1997 Doctoral fellowship from the DFG Graduate School “Molecular Pathophysiology of Cell Growth”
1998-2000 Travelling Research Fellowship of the Wellcome Trust, UK
2000-2001 Postdoctoral fellowship of the Max-Planck-Society
2011 Award for the best Habilitation of the University Medicine Göttingen


Current scientific research


Original paper

Schäffner I, Wittmann MT, Vogel T, Lie DC. Differential vulnerability of adult neurogenic niches to dosage of the Neurodevelopmental-disorder linked gene Foxg1. Mol. Psychiachtry. (2022).

Treppner M, Salas-Bastos A, Hess M, Lenz S, Vogel T, Binder H.Synthetic single cell RNA sequencing data from small pilot studies using deep generative models. Sci Rep. 11(1):9403-11. (2021).

Ferrari F, Arrigoni L, Franz H, Izzo A, Butenko L, Trompouki E, Vogel T, Manke T.  DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility. Nat Commun 11, 5200 (2020).

Gray de Cristoforis A, Ferrari F, Clotman F, Vogel T. Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. Mol Brain. 2020;13(1):85. Published 2020 May 29.

Franz H, Villarreal A, Heidrich S, Videm P, Kilpert F, Mestres I, Calegari F, Backofen R, Manke T, Vogel T (2019) DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex. Nucleic Acids Res 47(1):168-183

Bovio PP, Franz H, Heidrich S, Rauleac T, Kilpert F, Manke T, Vogel T (2019) Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo. Mol Neuro (56): 4273-4287

Weise SC, Arumugam G, Villarreal A, Videm P, Heidrich S, Nebel N, Dumit VI, Sananbenesi F, Reimann V, Craske M, Schilling O, Hess W, Fischer A, Backofen R, Vogel T (2018) FOXG1 regulates PRKAR2B transcriptionally and posttranscriptionally via miR200 in the adult hippocampus. Mol Neuro(56):5188-5201

Weise SC, Villarreal A, Heidrich S, Dehghanian F, Schachtrup C, Nestel S, Schwarz J, Thedieck K, Vogel T (2018) TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal Forebrain. Front Cell Neurosci,12.

Hoffmann N, Weise SC, Marinaro F, Vogel T and De Pietri Tonelli D (2018) DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex. Front. Neurosci. 12:281.

Bovio P, Roidl D, Heidrich S, Vogel T, Franz H (2018) Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark. J Vis Exp Jan 26;(131).

Grassi D, Franz H, Vezzali R, Bovio P, Heidrich S, Dehghanian F, Lagunas N, Belzung C, Krieglstein K, Vogel T (2017) Neuronal Activity, TGFβ-Signaling and Unpredictable Chronic Stress Modulate Transcription of Gadd45 Family Members and DNA Methylation in the Hippocampus. Cereb Cortex:1–16.

Ehrmann I, Gazzara MR, Pagliarini V, Dalgliesh C, Chadegani MK, Xu Y, Cesari E, Danilenko M, Maclennan M, Lowdon K, Vogel T, Keskivali-Bond P, Wells S, Cater H, Fort P, Koref MS, Middei S, Sette C, Clowry GJ, Barash Y, Cunningham M, Elliott DJ (2016) A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior. Cell Rep 17(12):3269-3280.

Seehusen FA, Kiel K, Jottini S, Wohlsein P, Habierski A, Seibel K, Vogel T, Urlaub H, Kollmar M, Baumgärtner W, Teichmann U (2016) Axonopathy in the Central Nervous System Is the Hallmark of Mice with a Novel Intragenic Null Mutation of Dystonin. Genetics. 204(1): 191-203.

Vezzali R, Weise SC, Hellbach N, Machado V, Heidrich S, Vogel T (2016) The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Oncotarget, 7(25): 37436-37455.

Roidl D, Hellbach N, Bovio P, Villarreal A, Heidrich S, Nestel S, Grüning B, Bönisch U, Vogel T (2016) DOT1L activity promotes proliferation and protects cortical neural stem cells from activation of ATF4-DDIT3-mediated ER stress in vitro. Stem Cells 34(1):  233-45.

Kosinsky RL, Wegwitz F, Hellbach N, Dobbelstein M, Mansouri A, Vogel T, Begus-Nahrmann Y, Johnsen SA (2015) Usp22 deficiency impairs intestinal epithelial lineage specification in vivo. Oncotarget 6(35):37906-18.

Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T (2014) Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet 23(23):6177-90.

Wahane SD, Hellbach N, Prentzell MT, Weise SC, Vezzali R, Kreutz C, Timmer J, Krieglstein K, Thedieck K, Vogel T (2014) PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2. J Neurochem.130(2): 255-67.

Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, Snaidero N, Vogel T, Shchebet TA, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beissbarth T, Johnsen SA (2012) The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells. Molecular Cell 46(5): 705–713.

Büttner N, Johnsen SA, Kügler S, Vogel T (2010) Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.Proc Natl Acad Sci U S A 107(15): 7042-7.

Overview articles

Akol I., Gather F., Vogel T. Paving Therapeutic Avenues for FOXG1 Syndrome: Untangling Genotypes and Phenotypes from a Molecular Perspective. Int J Mol Sci 23: 954. 2022.
Villarreal A., Vogel T. Different flavors of astrocytes: Revising the origins of astrocyte diversity and epigenetic signatures to understand heterogeneity after injury. Int J Mol Sci, 22:6867. 2022.
Hou PS, hAilín DÓ, Vogel T, Hanashima C. Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders. Front Cell Neurosci. 2020;14:35. Published 2020 Feb 25.
Vogel T, Lassmann S (2014) Epigenetics: development, dynamics and disease. Cell Tissue Res. 356:451-455.
Backofen R, Vogel T (2014) Biological and bioinformatical approaches to study crosstalk of long-non-coding RNAs and chromatin-modifying proteins. Cell Tissue Res. 356:507-526.
Roidl D, Hacker C (2014) Histone methylation during neural development. Cell Tissue Res. 356:539-552.
Vogel T, Schmidtke J (1998) Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein". Cytogenet Cell Genet 80: 209-213.

Publications 1996-1999

Publications 2000-2009

Book chapter
Insulin/IGF-Signalling in Embryonic and Adult Neural Proliferation and Differentiation in the Mammalian Central Nervous System


Scientific publications in Medline

Research Database University Freiburg

Other Ressources

NWG-Brain Project