What We've Done
Selected PublicationsThe most up-to-date list is at Pubmed |
Conforti P, Mezey S, Nath S, Chu YH, Malik SC, Martínez Santamaría JC, Deshpande SS, Pous L, Zieger B, Schachtrup C. Fibrinogen regulates lesion border-forming reactive astrocyte properties after vascular damage. Glia, 2022, 70:1251-1266. doi: 10.1002/glia.24166 |
Malik SC, Sozmen E, Baeza-Raja B, Le Moan N, Akassoglou K, Schachtrup C, In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target. Trends Pharmacol Sci, 2021, 42:43. doi: 10.1016/j.tips.2021.06.006 |
Pous L, Deshpande S, Nath S, Schildge S, Bohrer C, Topp K, Pfeifer D, Fernández-Klett F , Doostkam S, Galanakis DK, Taylor V, Akassoglou K, Schachtrup C. Fibrinogen Induces Neural Stem Cell Differentiation Into Astrocytes in the Subventricular Zone via BMP Signaling. Nat Comm, 2020, 11:630 doi:10.1038/s41467-020-14466-y |
Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron, 2017, 96:1003-1012. doi:10.1016/j.neuron.2017.10.008 |
Pfurr S, Chu YH, Bohrer C, Greulich F, Beattie R, Mammadzada K, Hils M, Arnold SJ, Taylor V, Schachtrup K, Uhlenhaut NH, Schachtrup C. The E2A splice variant E47 regulates the differentiation of projection neurons via p57 (KIP2) during cortical development. Development, 2017, 144:3917-3931, doi:10.1242/dev.145698 |
Bohrer C, Schachtrup C. ID(ealizing) control of adult subventricular zone neural stem/precursor cell differentiation for CNS regeneration. Neurogenesis, 2016, 3(1):e1223532, doi:10.1080/23262133.2016.1223532. Bohrer C, Pfurr S, Mammadzada K, Schildge S, Plappert L, Hils M, Pous L, Rauch K, Dumit V, Pfeifer D, Dengjel J, Kirsch M, Schachtrup K, Schachtrup C.The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes. EMBO J, 2015, 34:2804-19 doi: 10.15252/embj.201591118 |
Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Perez A, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. Nuclear pore complex remodeling by the cleaved p75 neurotrophin receptor regulates TGF-beta signaling and astrocyte scar formation. Nat Neurosci, 2015, 18:1077-80 doi:10.1038/nn.4054 |
Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR,Olefsky JM, Akassoglou K. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A, 2012, 109:5838-5843, doi:10.1073/pnas.1103638109 |
Schachtrup C, Ryu JK, Helmrick M, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. Fibrinogen triggers astrocyte scar formation by promoting availability of active TGF-β after vascular damage. J Neurosci, 2010, 30:5843-5854, doi:10.1523/JNEUROSCI.0137-10.2010 |
Friedman B, Schachtrup C, Tsai PS, Shih AY, Akassoglou K, Kleinfeld D, Lyden PD Acute vascular disruption and Aquaporin 4 loss after stroke. Stroke, 2009, 40:2182-2190, doi:10.1161/STROKEAHA.108.523720 |
Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson R, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature, 2008, 453:807-811, doi:10.1038/nature06905 |
Schachtrup C, Lu P, Jones LL, Lee JK, Lu J, Sachs BD, Zheng B, Akassoglou K Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci USA, 2007, 104:11814-11819, doi: 10.1073/pnas.0704045104 |
Sachs BD, Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, Mackenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol, 2007, 177:1119-1132, doi:10.1083/jcb.200701040 |