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Prof. Dr. Tanja Vogel

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Prof. Dr. Tanja Vogel

Institute of Anatomy and Cell Biology
University of Freiburg
Albertstr. 17
D-79104 Freiburg

Tel.: +49-761-203 5086
Fax: +49-761-203 5091

E-Mail

 

Curriculum vitae

1. General Information  
Name Vogel, Tanja, Prof. Dr.
Position Professor (W3)
2. Scientific education  
10/1988-01/1994

Study of Biochemistry, University of Hannover

3. Scientific Education and Appointments
07/1994-11/1997 PhD in human genetics, Instiute for Human Genetics, Hannover Medical School
2010 Habilitation in Anatomy, Universitäty Medicine Göttingen, Department of Neuroanatomy
4. Professional Career  
10/1997-01/2000 Postdoctoral fellow,MRC Human Genetics Unit, Edinburgh, UK
02/2000-07/2005 Postdoctoral fellow, MPI for Biophysical Chemistry, Göttingen
08/2005-03/2011 Group leader, Department of Neuroanatomy, Centre of Anatomy, University Medicine Göttingen
04/2011-01/2016 Associate Professor (W2), Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg
04/2014-10/2016 Managing Director of the Institute for Anatomy and Cell Biology, University of Freiburg
01/2016-present Professor (W3), Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg
5. Other Qualifications  
1994-1997 Doctoral fellowship from the DFG Graduate School “Molecular Pathophysiology of Cell Growth”
1998-2000 Travelling Research Fellowship of the Wellcome Trust, UK
2000-2001 Postdoctoral fellowship of the Max-Planck-Society
2011 Award for the best Habilitation of the University Medicine Göttingen

 

Current scientific research

Publications

Original paper

Franz H, Villarreal A, Heidrich S, Videm P, Kilpert F, Mestres I, Calegari F, Backofen R, Manke T, Vogel T (2019) DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex. Nucleic Acids Res 47(1):168-183
https://doi.org/10.1093/nar/gky953

Bovio PP, Franz H, Heidrich S, Rauleac T, Kilpert F, Manke T, Vogel T (2019) Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo. Mol Neurobiol. Mol Neuro (56): 4273-4287
https://doi.org/10.1007/s12035-018-1377-1

Weise SC, Arumugam G, Villarreal A, Videm P, Heidrich S, Nebel N, Dumit VI, Sananbenesi F, Reimann V, Craske M, Schilling O, Hess W, Fischer A, Backofen R, Vogel T (2018) FOXG1 regulates PRKAR2B transcriptionally and posttranscriptionally via miR200 in the adult hippocampus. Mol. Neurobiol. Mol Neuro(56):5188-5201
https://doi.org/10.1007/s12035-018-1444-7

Weise SC, Villarreal A, Heidrich S, Dehghanian F, Schachtrup C, Nestel S, Schwarz J, Thedieck K, Vogel T (2018) TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal Forebrain. Front Cell Neurosci,12.
http://doi.org/10.3389/fncel.2018.00448

Hoffmann N, Weise SC, Marinaro F, Vogel T and De Pietri Tonelli D (2018) DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex. Front. Neurosci. 12:281.
http://doi.org/10.3389/fnins.2018.00281

Bovio P, Roidl D, Heidrich S, Vogel T, Franz H (2018) Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark. J Vis Exp Jan 26;(131).
https://doi.org/10.3791/56631

Grassi D, Franz H, Vezzali R, Bovio P, Heidrich S, Dehghanian F, Lagunas N, Belzung C, Krieglstein K, Vogel T (2017) Neuronal Activity, TGFβ-Signaling and Unpredictable Chronic Stress Modulate Transcription of Gadd45 Family Members and DNA Methylation in the Hippocampus. Cereb Cortex:1–16.
https://doi.org/10.1093/cercor/bhx095

Ehrmann I, Gazzara MR, Pagliarini V, Dalgliesh C, Chadegani MK, Xu Y, Cesari E, Danilenko M, Maclennan M, Lowdon K, Vogel T, Keskivali-Bond P, Wells S, Cater H, Fort P, Koref MS, Middei S, Sette C, Clowry GJ, Barash Y, Cunningham M, Elliott DJ (2016) A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior. Cell Rep 17(12):3269-3280.
https://doi.org/10.1016/j.celrep.2016.12.002

Seehusen FA, Kiel K, Jottini S, Wohlsein P, Habierski A, Seibel K, Vogel T, Urlaub H, Kollmar M, Baumgärtner W, Teichmann U (2016) Axonopathy in the Central Nervous System Is the Hallmark of Mice with a Novel Intragenic Null Mutation of Dystonin. Genetics. 204(1): 191-203.
https://doi.org/10.1534/genetics.116.186932

Vezzali R, Weise SC, Hellbach N, Machado V, Heidrich S, Vogel T(2016) The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Oncotarget, 7(25): 37436-37455.
https://doi.org/10.18632/oncotarget.9545

Roidl D, Hellbach N, Bovio P, Villarreal A, Heidrich S, Nestel S, Grüning B, Bönisch U, Vogel T (2016) DOT1L activity promotes proliferation and protects cortical neural stem cells from activation of ATF4-DDIT3-mediated ER stress in vitro. Stem Cells 34(1):  233-45.
https://doi.org/10.1002/stem.2187

Kosinsky RL, Wegwitz F, Hellbach N, Dobbelstein M, Mansouri A, Vogel T, Begus-Nahrmann Y, Johnsen SA (2015) Usp22 deficiency impairs intestinal epithelial lineage specification in vivo. Oncotarget 6(35):37906-18.
https://doi.org/10.18632/oncotarget.5412

Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T (2014) Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet 23(23):6177-90.
https://doi.org/10.1093/hmg/ddu338

Wahane SD, Hellbach N, Prentzell MT, Weise SC, Vezzali R, Kreutz C, Timmer J, Krieglstein K, Thedieck K, Vogel T (2014) PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2. J Neurochem.130(2): 255-67.
https://doi.org/10.1111/jnc.12718

Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, Snaidero N, Vogel T, Shchebet TA, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beissbarth T, Johnsen SA (2012) The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells. Molecular Cell 46(5): 705–713.
https://doi.org/10.1016/j.molcel.2012.05.022

Büttner N, Johnsen SA, Kügler S, Vogel T (2010) Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.Proc Natl Acad Sci U S A 107(15): 7042-7.
https://doi.org/10.1073/pnas.0912041107

Overview articles

Vogel T, Lassmann S (2014) Epigenetics: development, dynamics and disease. Cell Tissue Res. 356:451-455.
https://doi.org/10.1007/s00441-014-1916-7
Backofen R, Vogel T (2014) Biological and bioinformatical approaches to study crosstalk of long-non-coding RNAs and chromatin-modifying proteins. Cell Tissue Res. 356:507-526.
https://doi.org/10.1007/s00441-014-1885-x
Roidl D, Hacker C (2014) Histone methylation during neural development. Cell Tissue Res. 356:539-552.
https://doi.org/10.1007/s00441-014-1842-8
Vogel T, Schmidtke J (1998) Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein". Cytogenet Cell Genet 80: 209-213.
https://doi.org/10.1159/000014982

Publications 1996-1999

Publications 2000-2009

Book chapter
Insulin/IGF-Signalling in Embryonic and Adult Neural Proliferation and Differentiation in the Mammalian Central Nervous System

 

Scientific publications in Medline

Research Database University Freiburg

Other Ressources

NWG-Brain Project

www.usegalaxy.eu